Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408566 | 0.79 | FYN (0.48) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7860122 | 0.78 | FYN (0.64) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7404035 | 0.78 | FYN (0.49) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7862705 | 0.73 | DRD3 (0.60) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL8899133 | 0.73 | DRD3 (0.60) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7862463 | 0.73 | DRD3 (0.60) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL8693035 | 0.72 | FYN (0.70) | FYNALDH1A1CYP2D6CYP2C9ALOX15 | |
| SCHEMBL7405367 | 0.71 | MEN1 (0.42) | FYNDRD3DRD2MEN1KMT2A | |
| SCHEMBL7450377 | 0.71 | DRD2 (0.43) | FYNDRD3DRD2DRD4 | |
| SCHEMBL8443814 | 0.71 | FYN (1.00) | FYNALDH1A1CYP2D6CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084130-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0923542-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997045403-A1 | ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-04 | — | — | WO | disclosed |