SCHEMBL7450409

SCHEMBL7450409

COc1cccc(CC(OC)OC)c1

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.70
IDO1 P14902 2/20 0.56
AGXT P21549 2/20 0.56
CHRM2 P08172 3/20 0.53
CHRM1 P11229 2/20 0.53
CHRM3 P20309 2/20 0.53
CMA1 P23946 1/20 0.51
SIGMAR1 Q99720 2/20 0.50
MAOB P27338 2/20 0.50
AOC3 Q16853 1/20 0.50
LPO P22079 1/20 0.49
SLC6A2 P23975 1/20 0.48
SLC6A4 P31645 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28684419 0.88 TAAR1 (0.60) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL449889 0.84 TAAR1 (0.76) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL48107 0.84 TAAR1 (0.55) TAAR1CMA1
SCHEMBL6204551 0.83 TAAR1 (0.64) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL151945 0.83 TAAR1 (0.74) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL6311891 0.83 TAAR1 (0.64) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL6204552 0.83 TAAR1 (0.64) TAAR1IDO1AGXTCHRM2CHRM1
SCHEMBL10501393 0.83 TAAR1 (0.64) TAAR1IDO1AGXTCHRM2CHRM1
(S)-M-Methoxyamphetamine SCHEMBL3293027 0.82 TAAR1 (1.00) TAAR1IDO1AGXTSIGMAR1SLC6A2
(S)-M-Methoxyamphetamine SCHEMBL11461072 0.82 TAAR1 (1.00) TAAR1IDO1AGXTSIGMAR1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265575-B1 THROMBIN INHIBITORS ELI LILLY AND COMPANY 2001-07-24 US disclosed
US-6251921-B1 ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL ELI LILLY AND COMPANY 2001-06-26 US disclosed
US-6025382-A Antithrombotic diamines ELI LILLY AND COMPANY (US) 2000-02-15 US disclosed
EP-0863755-A4 ANTITHROMBOTIC DIAMINES LILLY CO ELI (US) 1999-01-20 EP disclosed
EP-0863755-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1998-09-16 EP disclosed
WO-1997025033-A1 ANTITHROMBOTIC DIAMINES ELI LILLY AND COMPANY (US) 1997-07-17 WO disclosed
EP-0145252-B1 INOTROPIC AGENTS ELI LILLY AND COMPANY (US) 1988-03-02 EP disclosed
US-4533734-A ANTICOAGULANTS, BRONCHODILATORS, VASODILATORS ELI LILLY AND COMPANY (US) 1985-08-06 US disclosed
EP-0145252-A1 Inotropic agents ELI LILLY AND COMPANY (US) 1985-06-19 EP disclosed