Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.64 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | AGXT | P21549 | 2/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450409 | 0.83 | TAAR1 (0.70) | TAAR1IDO1AGXTCMA1CHRM2 | |
| SCHEMBL17330016 | 0.81 | TAAR1 (0.68) | TAAR1IDO1AGXTCMA1CHRM2 | |
| SCHEMBL3163360 | 0.80 | TAAR1 (0.71) | TAAR1IDO1AGXTCMA1ALDH1A1 | |
| SCHEMBL6205345 | 0.80 | IDO1 (0.47) | TAAR1IDO1ALDH1A1 | |
| SCHEMBL449889 | 0.79 | TAAR1 (0.76) | TAAR1IDO1AGXTCMA1CHRM2 | |
| SCHEMBL10501393 | 0.79 | TAAR1 (0.64) | TAAR1IDO1AGXTCMA1ALDH1A1 | |
| SCHEMBL6204552 | 0.79 | TAAR1 (0.64) | TAAR1IDO1AGXTCMA1CHRM2 | |
| SCHEMBL151945 | 0.79 | TAAR1 (0.74) | TAAR1IDO1AGXTCMA1CHRM2 | |
| SCHEMBL6204382 | 0.79 | SLC1A1 (0.46) | TAAR1IDO1AGXT | |
| SCHEMBL6203635 | 0.79 | PNMT (0.58) | TAAR1IDO1AGXTCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |