Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.65 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.65 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | GCGR | P47871 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337044 | 0.99 | KDM4E (0.68) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL4543175 | 0.94 | PSMB1 (0.75) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| Water SCHEMBL8476776 | 0.93 | PSMB1 (0.73) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL7443953 | 0.93 | PSMB1 (0.78) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL8475814 | 0.93 | PSMB1 (0.73) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| Water SCHEMBL8476448 | 0.91 | PSMB1 (0.76) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| Hydrochloric Acid SCHEMBL7451065 | 0.91 | PSMB1 (0.76) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL7447270 | 0.83 | SMN1; SMN2 (0.61) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL8641421 | 0.82 | PSMB1 (0.62) | KDM4EALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL7441221 | 0.82 | ESR1 (0.49) | KDM4EALDH1A1PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948796-A | OSTEOPOROSIS, CANCER, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |