Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.61 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067838 | 0.92 | GRM5 (0.59) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL12065522 | 0.90 | GRM5 (0.62) | GRM5SMARCA2SMARCA4GRM4GRM1 | |
| SCHEMBL7452726 | 0.89 | GRM5 (0.58) | GRM5SMARCA2SMARCA4THRBNPC1 | |
| SCHEMBL12067836 | 0.81 | GRM5 (0.52) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7459153 | 0.80 | GRM5 (0.72) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7453851 | 0.78 | GRM5 (0.69) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7445410 | 0.76 | GRM5 (1.00) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7454651 | 0.75 | GRM5 (0.52) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7454592 | 0.73 | GRM5 (0.68) | GRM5SMARCA2SMARCA4GRM4NPC1 | |
| SCHEMBL7453211 | 0.73 | GRM5 (0.55) | GRM5SMARCA2SMARCA4GRM4SMURF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |