Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.72 |
| ▸ | SMARCA2 | P51531 | 7/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453851 | 0.92 | GRM5 (0.69) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7458429 | 0.91 | GRM5 (0.61) | GRM5SMARCA2SMARCA4MEN1MAPT | |
| SCHEMBL7458646 | 0.90 | GRM5 (0.73) | GRM5SMARCA2SMARCA4MEN1MAPT | |
| SCHEMBL7454592 | 0.89 | GRM5 (0.68) | GRM5SMARCA2SMARCA4MAPTGRM4 | |
| SCHEMBL7454043 | 0.86 | GRM5 (0.71) | GRM5SMARCA2SMARCA4MEN1MAPT | |
| SCHEMBL7445410 | 0.84 | GRM5 (1.00) | GRM5SMARCA2SMARCA4MAPTCSNK1E | |
| SCHEMBL7453711 | 0.83 | GRM5 (0.58) | GRM5SMARCA2SMARCA4MEN1KMT2A | |
| SCHEMBL7446764 | 0.81 | GRM5 (0.52) | GRM5SMARCA2SMARCA4MEN1MAPT | |
| SCHEMBL7450747 | 0.80 | GRM5 (0.61) | GRM5SMARCA2SMARCA4CNR1CNR2 | |
| SCHEMBL7454077 | 0.80 | GRM5 (0.58) | GRM5SMARCA2SMARCA4MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |