Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24514125 | 0.83 | KDM4E (0.52) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL16800188 | 0.81 | TRPV1 (0.63) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL2058808 | 0.81 | ITGB1 (0.48) | MAPTPOLBKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL12668375 | 0.76 | KDM4E (0.65) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL6038366 | 0.76 | HSP90AA1 (0.43) | TDP1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL31647266 | 0.75 | KDM4E (0.60) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL19251340 | 0.75 | RAB9A (0.75) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL16800163 | 0.74 | KDM4E (0.58) | MAPTABL1POLBRIN1TDP1 | |
| SCHEMBL4413890 | 0.74 | POLB (0.50) | POLBKDM4EKMT2A | |
| SCHEMBL104605 | 0.72 | NPC1 (0.71) | MAPTKDM4ETRPV1FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001974-A1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006434-A1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS INC. (US) | 1999-02-11 | — | — | WO | claimed |