Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.55 |
| ▸ | ITGAV | P06756 | 11/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.55 |
| ▸ | ITGB5 | P18084 | 8/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 7/20 | 0.54 |
| ▸ | ESRRG | P62508 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452852 | 0.88 | ITGB3 (0.57) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7450342 | 0.87 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7450839 | 0.86 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7448307 | 0.85 | ITGB3 (0.58) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7450258 | 0.84 | ITGB3 (0.54) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL6491815 | 0.83 | ITGB3 (0.47) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL6494656 | 0.83 | ITGB3 (0.44) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7451824 | 0.82 | ITGB3 (0.47) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL7451827 | 0.82 | ITGB3 (0.47) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL6493323 | 0.82 | ITGB3 (0.48) | ITGB3ITGAVITGA2BITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187825-A1 | THIOPHENE INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2002-03-20 | — | — | EP | disclosed |
| US-6274620-B1 | 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION | BIOCHEM PHARMA INC. (CA) | 2001-08-14 | — | — | US | disclosed |
| WO-2000075129-A1 | THIOPHENE INTEGRIN INHIBITORS | SHIRE BIOCHEM INC. (CA) | 2000-12-14 | — | — | WO | disclosed |