Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.44 |
| ▸ | ITGAV | P06756 | 8/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492757 | 0.88 | ITGB3 (0.48) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL6493323 | 0.88 | ITGB3 (0.48) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL8902514 | 0.85 | ITGAV (0.52) | ITGB3ITGA2BITGAVUSP2 | |
| SCHEMBL7450546 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL7451824 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL7451827 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL6494179 | 0.84 | ITGB3 (0.42) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL7450342 | 0.83 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL7450849 | 0.83 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB5ITGB1 | |
| SCHEMBL6502445 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BITGAVITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960594-B2 | Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer | SHIRE BIOCHEM INC. (CA) | 2005-11-01 | — | — | US | disclosed |
| EP-1091952-B1 | THIOPHENE AND FURAN 2,5-DICARBOXAMIDES USEFUL IN THE TREATMENT OF CANCER | IAF BIOCHEM INT (CA) | 2003-10-29 | — | — | EP | disclosed |
| US-20020137947-A1 | Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer | BIOCHEM PHARMA INC. | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137947-A1 | Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer | ITGB5, ITGB2, ITGA2 | ITGB3 12/4885ITGA2B 10/4885ITGAV 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.