Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 7/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182197 | 0.93 | ESRRG (0.46) | ESRRGESRRBALDH1A1MAPTKDM4E | |
| SCHEMBL7452250 | 0.88 | HDAC1 (0.49) | ALDH1A1KDM4EHTTNPC1RAB9A | |
| SCHEMBL7452326 | 0.83 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6182799 | 0.83 | LMNA (0.45) | ESRRGALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL7450457 | 0.81 | MCHR1 (0.43) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7554411 | 0.81 | EPHX2 (0.50) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7453120 | 0.80 | NAMPT (0.41) | HTTNPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL6184113 | 0.80 | KDM4E (0.54) | KDM4E | |
| SCHEMBL6183529 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7449982 | 0.78 | POLB (0.47) | ALDH1A1MAPTKDM4EGFERNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161415-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055126-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |