SCHEMBL745175

SCHEMBL745175

COC(=O)Nc1nc2ccccc2n1C(=O)NCCSC.Cc1cc(C)n(-c2nc3ccccc3[nH]2)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.52
TSHR P16473 3/20 0.52
KDM4E B2RXH2 7/20 0.45
TDP1 Q9NUW8 7/20 0.45
MAPT P10636 11/20 0.44
HTT P42858 6/20 0.44
LMNA P02545 4/20 0.44
MAPK1 P28482 2/20 0.44
SMN1; SMN2 Q16637 7/20 0.42
HSD17B10 Q99714 2/20 0.41
NPSR1 Q6W5P4 8/20 0.41
KMT2A Q03164 8/20 0.41
MEN1 O00255 7/20 0.41
HPGD P15428 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
POLB P06746 2/20 0.41
NPC1 O15118 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL159671 0.82 TSHR (0.74) ALDH1A1TSHRKDM4ETDP1MAPT
Fuberidazole SCHEMBL22833870 0.78 ALDH1A1 (0.54) ALDH1A1TSHRKDM4ETDP1MAPT
Benomyl SCHEMBL447867 0.73 ALDH1A1 (0.80) ALDH1A1TSHRMAPTHTTLMNA
SCHEMBL205803 0.72 TSHR (0.87) ALDH1A1TSHRKDM4ETDP1HTT
SCHEMBL9578798 0.71 TSHR (0.78) ALDH1A1TSHRKDM4ETDP1LMNA
SCHEMBL28539606 0.71 TSHR (0.53) ALDH1A1TSHRMAPTLMNAMAPK1
SCHEMBL21295 0.70 KMT2A (0.70) ALDH1A1TSHRKDM4ETDP1MAPT
SCHEMBL29668346 0.70 KMT2A (0.70) ALDH1A1TSHRKDM4ETDP1MAPT
Benomyl SCHEMBL29379464 0.70 TSHR (1.00) ALDH1A1TSHRKDM4EHTTLMNA
Benomyl SCHEMBL15681 0.70 TSHR (1.00) ALDH1A1TSHRKDM4EHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2431430-B1 THE USE OF MICRONIZED WOOD PRESERVATIVE FORMULATIONS IN ORGANIC CARRIERS KOPPERS PERFORMANCE CHEMICALS INC (US) 2017-02-01 EP disclosed
EP-1799776-B1 MICRONIZED WOOD PRESERVATIVE FORMULATIONS IN ORGANIC CARRIERS OSMOSE INC (US) 2013-01-02 EP disclosed
EP-2431430-A1 Micronized wood preservative formulations in organic carriers Osmose, Inc. (US) 2012-03-21 EP disclosed
EP-1799776-A4 MICRONIZED WOOD PRESERVATIVE FORMULATIONS IN ORGANIC CARRIERS OSMOSE INC (US) 2009-05-06 EP disclosed
EP-1799776-A2 MICRONIZED WOOD PRESERVATIVE FORMULATIONS IN ORGANIC CARRIERS Osmose, Inc. (US) 2007-06-27 EP disclosed
WO-2006044831-A2 NON-ALKALINE MICRONIZED WOOD PRESERVATIVE FORMULATIONS OSMOSE, INC. (US) 2006-04-27 WO disclosed
WO-2006044218-A2 MICRONIZED WOOD PRESERVATIVE FORMULATIONS IN ORGANIC CARRIERS OSMOSE, INC. (US) 2006-04-27 WO disclosed