Benomyl

Benomyl

SCHEMBL447867

CCCCNC(=O)n1c(NC(=O)OC)nc2ccccc21.COC(=O)Nc1nc2ccccc2[nH]1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.80
TSHR P16473 2/20 0.80
ASAH1 Q13510 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
LMNA P02545 6/20 0.48
CYP1A2 P05177 4/20 0.48
HIF1A Q16665 3/20 0.48
TUBB4A P04350 1/20 0.48
TUBB P07437 1/20 0.48
TUBA3C P0DPH7 1/20 0.48
CYP2D6 P10635 1/20 0.48
TUBA1B P68363 1/20 0.48
TUBA4A P68366 1/20 0.48
TUBB4B P68371 1/20 0.48
TUBB3 Q13509 1/20 0.48
TUBB2A Q13885 1/20 0.48
TUBB8 Q3ZCM7 1/20 0.48
TUBA3E Q6PEY2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benomyl SCHEMBL3962065 0.90 TSHR (0.98) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL8379451 0.89 TSHR (1.00) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL29379464 0.89 TSHR (1.00) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL15681 0.89 TSHR (1.00) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Thiophanate SCHEMBL2132544 0.89 ALDH1A1 (0.62) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL28267707 0.88 ALDH1A1 (0.66) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL28721488 0.86 TSHR (0.94) ALDH1A1TSHRASAH1RAB9ALMNA
Benomyl SCHEMBL27841656 0.86 TSHR (0.94) ALDH1A1TSHRASAH1SMN1; SMN2RAB9A
Benomyl SCHEMBL5269084 0.85 TSHR (0.58) ALDH1A1TSHRASAH1SMN1; SMN2NPC1
Benomyl SCHEMBL23632884 0.85 TSHR (0.92) ALDH1A1TSHRASAH1LMNAUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210022343-A1 FUNGICIDAL COMBINATIONS UPL LTD (IN) 2021-01-28 US claimed
EP-2516558-B1 NETWORK COPOLYMER CROSSLINKED COMPOSITIONS AND PRODUCTS COMPRISING THE SAME MOMENTIVE PERFORMANCE MAT INC (US) 2017-09-27 EP claimed
EP-2236029-B1 Hydrolysis resistant organomodified trisiloxane surfactants MOMENTIVE PERFORMANCE MAT INC (US) 2016-09-21 EP claimed
US-9200119-B2 Silicon-containing zwitterionic linear copolymer composition MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-12-01 US claimed
WO-2014074299-A1 SILICON-CONTAINING ZWITTERIONIC LINEAR COPOLYMER COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-05-15 WO claimed
US-20140134126-A1 SILICON-CONTAINING ZWITTERIONIC LINEAR COPOLYMER COMPOSITION MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-05-15 US claimed
EP-2516558-A1 NETWORK COPOLYMER CROSSLINKED COMPOSITIONS AND PRODUCTS COMPRISING THE SAME Momentive Performance Materials Inc. (US) 2012-10-31 EP claimed
EP-2136622-B1 HYDROLYSIS RESISTANT ORGANOMODIFIED TRISILOXANE SURFACTANTS MOMENTIVE PERFORMANCE MAT INC (US) 2012-08-08 EP claimed
EP-2236028-B1 Agrochemical composition containing an hydrolysis resistant organomodified trisiloxane surfactant MOMENTIVE PERFORMANCE MAT INC (US) 2012-05-16 EP claimed
EP-2449879-A1 Hydrolysis resistant organomodified trisiloxane surfactants Momentive Performance Materials Inc. (US) 2012-05-09 EP claimed
EP-1973402-A2 EXTREME ENVIRONMENT SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS Momentive Performance Materials Inc. (US) 2008-10-01 EP claimed
EP-1971205-A2 EXTREME ENVIRONMENTAL SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS Momentive Performance Materials Inc. (US) 2008-09-24 EP claimed
WO-2008111928-A1 HYDROLYSIS RESISTANT ORGANOMODIFIED TRISILOXANE SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2008-09-18 WO claimed
WO-2007139615-A2 USE OF HYDROLYSIS RESISTANT ORGANOMODIFIED SILYLATED SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-12-06 WO claimed
US-20070269467-A1 Use of hydrolysis resistant organomodified silylated surfactants MOMENTIVE PERFORMANCE MATERIALS INC. 2007-11-22 US claimed
US-20070197394-A1 Hydrolysis resistant organomodified trisiloxane surfactants GENERAL ELECTRIC COMPANY 2007-08-23 US claimed
WO-2007089330-A2 EXTREME ENVIRONMENT SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-08-09 WO claimed
WO-2007070469-A2 EXTREME ENVIRONMENTAL SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2007-06-21 WO claimed
US-20070135308-A1 Extreme environment surfactant compositions comprising hydrolysis resistant organomodified disiloxane surfactants GENERAL ELECTRIC COMPANY 2007-06-14 US claimed
US-20070087937-A1 EXTREME ENVIRONMENT SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS MOMENTIVE PERFORMANCE MATERIALS INC. 2007-04-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197394-A1 Hydrolysis resistant organomodified trisiloxane surfactants MDM4, MSMO1, MGLL ALDH1A1 3461/4885TSHR 1665/4885ASAH1 1483/4885
US-20070087937-A1 EXTREME ENVIRONMENT SURFACTANT COMPOSITIONS COMPRISING HYDROLYSIS RESISTANT ORGANOMODIFIED DISILOXANE SURFACTANTS HDHD5, P4HB, MCM6 ALDH1A1 4342/4885TSHR 2050/4885ASAH1 659/4885
US-20210022343-A1 FUNGICIDAL COMBINATIONS AS3MT, CYP3A43, CYP3A7 ALDH1A1 705/4885TSHR 1400/4885ASAH1 2002/4885
US-20070269467-A1 Use of hydrolysis resistant organomodified silylated surfactants CEL, LCT, SI ALDH1A1 3099/4885TSHR 1146/4885ASAH1 819/4885
US-20140134126-A1 SILICON-CONTAINING ZWITTERIONIC LINEAR COPOLYMER COMPOSITION ZW10, WIZ, ZYX ALDH1A1 4870/4885TSHR 1397/4885ASAH1 4349/4885
US-20070135308-A1 Extreme environment surfactant compositions comprising hydrolysis resistant organomodified disiloxane surfactants MSR1, HDHD5, TPD52L2 ALDH1A1 2583/4885TSHR 803/4885ASAH1 2186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.