Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451976 | 1.00 | CSNK2A2 (0.40) | CSNK2A2CSNK2A1CSNK2BHDAC1HDAC8 | |
| SCHEMBL7407492 | 0.81 | SMN1; SMN2 (0.43) | CSNK2A2CSNK2A1HDAC1HDAC8HDAC2 | |
| SCHEMBL7407491 | 0.81 | SMN1; SMN2 (0.43) | CSNK2A2CSNK2A1HDAC1HDAC8HDAC2 | |
| SCHEMBL10021382 | 0.80 | HDAC8 (0.48) | HDAC8TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL4426389 | 0.80 | HDAC8 (0.48) | HDAC8TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL4426383 | 0.80 | HDAC8 (0.48) | HDAC8TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL28120571 | 0.78 | ALOX15 (0.47) | HDAC8TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL7409718 | 0.78 | CSNK2A1 (0.42) | CSNK2A2CSNK2A1HDAC1HDAC8HDAC6 | |
| SCHEMBL7409716 | 0.78 | CSNK2A1 (0.42) | CSNK2A2CSNK2A1HDAC1HDAC8HDAC6 | |
| SCHEMBL7412483 | 0.77 | HDAC4 (0.41) | HDAC8HDAC4TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | claimed |
| WO-1999018079-A1 | HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-04-15 | — | — | WO | claimed |
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | disclosed |
| WO-1999018079-A1 | HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |