Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407492 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL7451976 | 0.81 | CSNK2A2 (0.40) | SMN1; SMN2MAPTALDH1A1HDAC8KDM4E | |
| SCHEMBL7451980 | 0.81 | CSNK2A2 (0.40) | SMN1; SMN2MAPTALDH1A1HDAC8KDM4E | |
| SCHEMBL7409716 | 0.80 | CSNK2A1 (0.42) | SMN1; SMN2RAB9AALDH1A1CYP1A2HDAC8 | |
| SCHEMBL7409718 | 0.80 | CSNK2A1 (0.42) | SMN1; SMN2RAB9AALDH1A1CYP1A2HDAC8 | |
| SCHEMBL7411447 | 0.79 | HDAC8 (0.43) | SMN1; SMN2RAB9AALDH1A1CYP1A2HDAC8 | |
| SCHEMBL7411451 | 0.79 | HDAC8 (0.43) | SMN1; SMN2RAB9AALDH1A1CYP1A2HDAC8 | |
| SCHEMBL7412488 | 0.79 | HDAC4 (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL7412483 | 0.79 | HDAC4 (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL7409280 | 0.77 | SLC6A7 (0.42) | SMN1; SMN2RAB9ACYP1A2HDAC8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | claimed |
| WO-1999018079-A1 | HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-04-15 | — | — | WO | claimed |
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | disclosed |
| WO-1999018079-A1 | HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |