SCHEMBL7452500

SCHEMBL7452500

[CH2]Nc1n[nH]c2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.54
KDM4E B2RXH2 5/20 0.52
GAA P10253 2/20 0.52
PDPK1 O15530 1/20 0.52
CYP3A4 P08684 1/20 0.52
FADS1 O60427 2/20 0.50
ADRA2A P08913 2/20 0.50
MAPK10 P53779 3/20 0.48
ALDH1A1 P00352 2/20 0.48
IDO1 P14902 2/20 0.48
ALPL P05186 1/20 0.48
HPGD P15428 1/20 0.48
TTK P33981 1/20 0.48
GRM4 Q14833 1/20 0.44
AURKA O14965 1/20 0.44
CYP1A2 P05177 1/20 0.44
YTHDC1 Q96MU7 1/20 0.43
STAT3 P40763 1/20 0.43
HIF1A Q16665 1/20 0.43
LRRK2 Q5S007 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15392392 0.79 TRPA1 (0.54) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL11700794 0.79 KDM4E (0.57) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL11756891 0.79 TRPA1 (0.54) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL7172053 0.79 TRPA1 (0.54) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL31032755 0.79 TRPA1 (0.54) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL700943 0.79 TRPA1 (0.50) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL628692 0.78 KDM4E (0.52) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL4741513 0.76 TRPA1 (0.75) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL29882003 0.76 TRPA1 (0.75) TRPA1KDM4EGAAPDPK1CYP3A4
SCHEMBL966349 0.75 TRPA1 (0.50) TRPA1KDM4EGAAPDPK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888344-A1 SPIROCYCLE INTEGRIN INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1999-01-07 EP disclosed
WO-1997033887-A1 SPIROCYCLE INTEGRIN INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1997-09-18 WO disclosed