⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16289693 | 0.71 | — | — | |
| SCHEMBL3760097 | 0.70 | KMT2A (0.41) | — | |
| SCHEMBL5576075 | 0.70 | CYP11B1 (0.48) | — | |
| SCHEMBL5576077 | 0.70 | CYP11B1 (0.48) | — | |
| SCHEMBL959376 | 0.67 | — | — | |
| SCHEMBL2654100 | 0.67 | — | — | |
| SCHEMBL8557626 | 0.66 | — | — | |
| SCHEMBL1200601 | 0.66 | CYP11B1 (0.58) | — | |
| SCHEMBL28330955 | 0.66 | ALDH1A1 (0.43) | — | |
| SCHEMBL4909130 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616711-A | REACTING BUTENE DERIVATIVE TO AN AMIDE DERIVATIVE; USEFUL AS INTERMEDIATES FOR PRODUCING ANTIULCER DRUGS | FUJIREBIO INC. (JP) | 1997-04-01 | — | — | US | claimed |
| EP-0582304-A2 | Methods of producing amino butene derivatives | FUJIREBIO Inc. (JP) | 1994-02-09 | — | — | EP | claimed |
| US-4800201-A | 1,4-thiazine derivative, and cardiotonic agent comprising it as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-24 | — | — | US | claimed |
| EP-0233287-A1 | 1,4-THIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND CARDIOTONICS CONTAINING THE SAME | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1987-08-26 | — | — | EP | claimed |
| CN-115960117-B | Sulfur-containing fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-2865666-B1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-31 | — | — | EP | disclosed |
| US-9567300-B2 | Hexahydropentaleno derivatives, preparation method and use in medicine thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-9475820-B2 | Substituted imidazo[1,2-a]pyrazines as TNF activity modulators | UCB BIOPHARMA SPRL (BE) | 2016-10-25 | — | — | US | disclosed |
| EP-2895490-B1 | GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE | SUNSHINE LAKE PHARMA CO LTD (CN) | 2016-10-19 | — | — | EP | disclosed |
| US-9394329-B2 | Glucopyranosyl derivatives and their uses in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-07-19 | — | — | US | disclosed |
| US-20150299118-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-0582304-A2 | Methods of producing amino butene derivatives | FUJIREBIO Inc. (JP) | 1994-02-09 | — | — | EP | disclosed |
| EP-0199968-B1 | THIAZOLE DERIVATIVES | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | disclosed |
| US-4804668-A | CARDIOTONIC AGENTS | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-02-14 | — | — | US | disclosed |
| US-4800201-A | 1,4-thiazine derivative, and cardiotonic agent comprising it as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-01-24 | — | — | US | disclosed |
| EP-0233287-A1 | 1,4-THIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND CARDIOTONICS CONTAINING THE SAME | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1987-08-26 | — | — | EP | disclosed |
| EP-0199968-A1 | Thiazole derivatives | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-11-05 | — | — | EP | disclosed |
| US-3978079-A | DIPHTHALIMIDO, DISUCCINIMIDO AND DIMALEIMIDO OXALATES | AMERICAN CYANAMID COMPANY (US) | 1976-08-31 | — | — | US | disclosed |
| US-3970660-A | BIS(1,2-DIHYDRO-2-OXO-1-PYRIDYL) GLYOXAL | AMERICAN CYANAMID COMPANY (US) | 1976-07-20 | — | — | US | disclosed |