Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.36 |
| ▸ | CDK2 | P24941 | 11/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.36 |
| ▸ | CDK1 | P06493 | 9/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134492 | 0.75 | PDPK1 (0.44) | NUDT1 | |
| SCHEMBL7452620 | 0.72 | CDK2 (0.47) | CDK2NUDT1 | |
| SCHEMBL2698213 | 0.72 | DPP4 (0.47) | NUDT1 | |
| SCHEMBL7458810 | 0.71 | PIN1 (0.64) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL5484380 | 0.70 | PNP (0.44) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| Methylguanine SCHEMBL29903462 | 0.68 | CDK1 (0.69) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| Methylguanine SCHEMBL231097 | 0.68 | CDK1 (0.69) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL9500277 | 0.68 | ENPP1 (0.40) | CCNA2CDK2CCNA1CDK1CCNB1 | |
| SCHEMBL16828220 | 0.65 | CCNA2 (0.38) | CCNA2CDK2CCNA1NUDT1 | |
| SCHEMBL16828162 | 0.64 | CCNA2 (0.50) | CCNA2CDK2CCNA1NUDT1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916674-B1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-05-08 | — | — | EP | disclosed |
| US-6342603-B1 | PREPARING CYCLOPROPANE RING-CLEAVED PURINE DERIVATIVE BY HYDROGENATING PURINE DERIVATIVE HAVING CYCLOPROPANE RING | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-01-29 | — | — | US | disclosed |
| US-6156892-A | Purine derivatives having cyclopropane ring | SUMIKA FIRE CHEMICALS CO., LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0916674-A1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |