Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443685 | 0.76 | ALOX15 (0.50) | KDM4EALDH1A1ALOX15KMT2AMTNR1A | |
| SCHEMBL13627365 | 0.69 | APP (0.49) | CYP1A2CYP2D6MAPK1CYP2C19DRD2 | |
| SCHEMBL12177908 | 0.67 | CYP1A2 (0.63) | CYP1A2CYP2D6MAPK1CYP2C19KDM4E | |
| SCHEMBL8128151 | 0.67 | ALDH1A1 (0.39) | ALDH1A1KMT2ATSHR | |
| SCHEMBL10659435 | 0.66 | KDM4E (0.46) | MAPK1KDM4EALDH1A1ALOX15GAA | |
| SCHEMBL8076606 | 0.66 | KDM4E (0.53) | CYP1A2CYP2D6MAPK1CYP2C19KDM4E | |
| SCHEMBL24571513 | 0.66 | KDM4E (0.47) | CYP1A2CYP2D6MAPK1CYP2C19KDM4E | |
| SCHEMBL7450154 | 0.66 | EPHX2 (0.39) | MAPK1ALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL19126180 | 0.65 | KDM4E (0.48) | CYP1A2CYP2D6MAPK1CYP2C19KDM4E | |
| SCHEMBL8766476 | 0.65 | KMT2A (0.54) | CYP1A2CYP2D6MAPK1CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541151-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |