Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11339085 | 0.83 | HCRTR1 (0.58) | TSHRALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL30218361 | 0.83 | NPC1 (0.62) | TSHRALDH1A1L3MBTL1CTNNB1MAPK1 | |
| SCHEMBL954173 | 0.83 | NPC1 (0.62) | TSHRALDH1A1L3MBTL1CTNNB1MAPK1 | |
| SCHEMBL10952718 | 0.81 | CTNNB1 (0.57) | TSHRALDH1A1L3MBTL1NPSR1CTNNB1 | |
| SCHEMBL538560 | 0.81 | SMN1; SMN2 (0.68) | TSHRALDH1A1L3MBTL1NPSR1CTNNB1 | |
| SCHEMBL6737969 | 0.81 | CTNNB1 (0.61) | TSHRALDH1A1L3MBTL1NPSR1CTNNB1 | |
| SCHEMBL377080 | 0.80 | ABCB1 (0.61) | ALDH1A1L3MBTL1MEN1KMT2AABCB1 | |
| SCHEMBL32688037 | 0.80 | TSHR (0.52) | TSHRALDH1A1MEN1KMT2AABCB1 | |
| SCHEMBL5753439 | 0.79 | ERCC5 (0.62) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL23149608 | 0.79 | FFAR4 (0.49) | TSHRALDH1A1L3MBTL1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040576-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-13 | — | — | WO | disclosed |