SCHEMBL7454907

SCHEMBL7454907

COc1cc(Cc2ncc(C=O)[nH]2)ccc1C#N

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.39
MAP2K1 Q02750 1/20 0.37
POLB P06746 1/20 0.37
NTRK1 P04629 1/20 0.36
IDH1 O75874 2/20 0.36
CACNA1H O95180 1/20 0.36
FNTA P49354 1/20 0.36
FNTB P49356 1/20 0.36
PGGT1B P53609 1/20 0.36
KCNJ1 P48048 1/20 0.36
KCNH2 Q12809 1/20 0.36
NSD2 O96028 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6409770 0.84 DAO (0.43) CACNA1H
SCHEMBL7841430 0.81 KCNJ1 (0.39) ARPOLBNTRK1CACNA1HKCNJ1
SCHEMBL7455068 0.81 AR (0.39) ARPOLBNTRK1CACNA1HFNTA
SCHEMBL6417855 0.81 GPR52 (0.37) ARCACNA1H
Hydrochloric Acid SCHEMBL7846069 0.79 S1PR1 (0.41) ARNTRK1CACNA1H
SCHEMBL6688212 0.78 TYMP (0.45) IDH1
Bromide SCHEMBL8005948 0.77 NTRK1 (0.36) NTRK1CACNA1HKCNJ1KCNH2
SCHEMBL7936020 0.75 DAO (0.49) CACNA1HKCNJ1KCNH2
SCHEMBL286682 0.73 AR (0.48) ARFNTAFNTBPGGT1BKCNJ1
SCHEMBL6414068 0.71 MEN1 (0.33) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019529-A4 A METHOD OF TREATING CANCER MERCK & CO INC (US) 2002-09-11 EP disclosed
EP-1053224-A1 BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT Aventis Pharma Deutschland GmbH (DE) 2000-11-22 EP disclosed
WO-2000059930-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 2000-10-12 WO disclosed
EP-1019530-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 2000-07-19 EP disclosed
EP-1019529-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 2000-07-19 EP disclosed
EP-1009854-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 2000-06-21 EP disclosed
WO-2000016626-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 2000-03-30 WO disclosed
WO-1999040064-A1 BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 1999-08-12 WO disclosed
WO-1999010525-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1999-03-04 WO disclosed
WO-1999010524-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1999-03-04 WO disclosed
WO-1999010523-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1999-03-04 WO disclosed