Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452537 | 0.92 | HDAC1 (0.49) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL7446916 | 0.86 | HDAC1 (0.50) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL4006566 | 0.85 | NAMPT (0.49) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL8214866 | 0.85 | NAMPT (0.49) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL7448308 | 0.81 | HDAC1 (0.52) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL7446767 | 0.80 | HDAC1 (0.48) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL7457288 | 0.80 | HDAC1 (0.53) | NAMPTHDAC1MEN1KMT2ANTSR1 | |
| SCHEMBL28736218 | 0.79 | LMNA (0.59) | HDAC1KMT2ACYP3A4CYP2C19MAPT | |
| SCHEMBL330450 | 0.79 | LMNA (0.59) | HDAC1KMT2ACYP3A4CYP2C19MAPT | |
| SCHEMBL6356699 | 0.79 | LMNA (0.59) | HDAC1KMT2ACYP3A4CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027096-A9 | AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | PROTHERICS MOLECULAR DESIGN LT (GB) | 2001-07-12 | — | — | WO | disclosed |
| WO-2001027096-A1 | AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | TULARIK LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |