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SCHEMBL330450

SCHEMBL330450

COC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.59
▸ HPGD P15428 1/20 0.59
▸ HDAC1 Q13547 1/20 0.54
▸ ALDH1A1 P00352 6/20 0.52
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ TP53 P04637 1/20 0.52
▸ GAA P10253 1/20 0.51
▸ KMT2A Q03164 1/20 0.50
▸ CYP1A2 P05177 2/20 0.47
▸ CYP2C9 P11712 2/20 0.47
▸ CYP2C19 P33261 2/20 0.47
▸ CYP3A4 P08684 2/20 0.47
▸ MAPT P10636 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ CTRB1 P17538 1/20 0.46
▸ PTGS1 P23219 1/20 0.46
▸ PTGS2 P35354 1/20 0.46
▸ NPC1 O15118 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1071825 1.00 LMNA (0.59) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL6356699 1.00 LMNA (0.59) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL28736218 1.00 LMNA (0.59) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL15819269 0.88 L3MBTL1 (0.51) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL15819271 0.88 L3MBTL1 (0.51) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL8608304 0.87 LMNA (0.55) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL14471579 0.87 LMNA (0.55) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL8608960 0.87 LMNA (0.55) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL6427442 0.87 LMNA (0.55) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2
SCHEMBL9276855 0.87 LMNA (0.55) LMNAHPGDHDAC1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056742-A1 PROCESS FOR PREPARING TAXOL SIDE CHAIN USING HETEROGENEOUS TRIFUNCTIONAL CATALYST COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-07-08 — — WO claimed
US-6706901-B1 HECK COUPLING OF BROMOBENZENE AND METHYL ACRYLATE AND N-OXIDATION OF AN AMINE IN PRESENCE OF CINCHONA ALKALOID USING ION EXCHANGER-PALLADIUM-OSMIUM-TUNGSTEN CATALYST TO PRODUCE 2,3-DIHYDROXY-3-PHENYLPROPIONATE; ONE POT PROCESS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-03-16 — — US claimed
CN-116297963-B Method for detecting sodium octoate content in albumin-combined taxol injection 四川汇宇制药股份有限公司 2024-12-27 — — CN disclosed
CN-116297963-A Method for detecting sodium octoate content in albumin-combined taxol injection 四川汇宇制药股份有限公司 2023-06-23 — — CN disclosed
WO-2023053054-A1 PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES INDENA S.P.A. (IT) 2023-04-06 — — WO disclosed
US-11119033-B2 Conformation analysis device, analysis method, conformational notation device and notation method Izumi, Hiroshi (JP) 2021-09-14 — — US disclosed
CN-107406371-B Process for producing 3-phenylisoserine derivative 东丽精细化工株式会社 2020-07-17 — — CN disclosed
EP-3266761-B1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD TORAY FINECHEMICALS CO LTD (JP) 2020-05-06 — — EP disclosed
US-10087139-B2 3-Phenylisoserine derivative production method TORAY FINE CHEMICALS CO., LTD. (JP) 2018-10-02 — — US disclosed
US-20180237384-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD TORAY FINE CHEMICALS CO., LTD. (JP) 2018-08-23 — — US disclosed
EP-3266761-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD Toray Fine Chemicals Co., Ltd. (JP) 2018-01-10 — — EP disclosed
US-5932758-A Process for the production β-amino-α-hydroxycarboxylic acids and derivatives thereof DEGUSSA AKTIENGESELLSCHAFT (DE) 1999-08-03 — — US disclosed
US-5859281-A Catalytic asymmetric aminohydroxylation of olefins with sulfonamides THE SCRIPPS RESEARCH INSTITUTE (US) 1999-01-12 — — US disclosed
EP-0844992-A1 PROCESS FOR PRODUCING $g(b)-AMINO-$g(a)-HYDROXYCARBOXYLIC ACIDS AND DERIVATIVES THEREOF Degussa Aktiengesellschaft (DE) 1998-06-03 — — EP disclosed
EP-0844992-A1 PROCESS FOR PRODUCING $g(b)-AMINO-$g(a)-HYDROXYCARBOXYLIC ACIDS AND DERIVATIVES THEREOF Degussa Aktiengesellschaft (DE) 1998-06-03 — — EP disclosed
WO-1997002236-A1 PROCESS FOR PRODUCING β-AMINO-α-HYDROXYCARBOXYLIC ACIDS AND DERIVATIVES THEREOF DEGUSSA AKTIENGESELLSCHAFT (DE) 1997-01-23 — — WO disclosed
WO-1997002236-A1 PROCESS FOR PRODUCING β-AMINO-α-HYDROXYCARBOXYLIC ACIDS AND DERIVATIVES THEREOF DEGUSSA AKTIENGESELLSCHAFT (DE) 1997-01-23 — — WO disclosed
US-5463106-A Process for the enantioselective preparation of phenylisosrine derivatives CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1995-10-31 — — US disclosed
US-5304670-A Process for the enantioselective preparation of phenylisoserine derivatives CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1994-04-19 — — US disclosed
WO-1993010076-A1 SYNTHESIS AND OPTICAL RESOLUTION OF THE TAXOL SIDE CHAIN AND RELATED COMPOUNDS THE UNIVERSITY OF MISSISSIPPI (US) 1993-05-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180237384-A1 3-PHENYLISOSERINE DERIVATIVE PRODUCTION METHOD SPTSSB, PIM3, TST LMNA 3094/4885HPGD 3334/4885HDAC1 603/4885
US-10087139-B2 3-Phenylisoserine derivative production method SPTSSB, PIM3, TST LMNA 3094/4885HPGD 3334/4885HDAC1 603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.