SCHEMBL7455751

SCHEMBL7455751

O=CC1C(=O)Oc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
ATM Q13315 1/20 0.40
CYP2C9 P11712 3/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
GAA P10253 3/20 0.37
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL68805 0.85 MAOA (0.52) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL30138896 0.85 MAOA (0.52) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL28808239 0.77 MEN1 (0.40) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL29808265 0.77 MEN1 (0.40) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL29810734 0.77 MEN1 (0.40) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL28743897 0.76 MAOA (0.38) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL16785724 0.72 MAOA (0.46) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL20785352 0.72 MAOA (0.46) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL20785351 0.72 MAOA (0.46) MAOAMAOBATMCYP2C9HDAC3
SCHEMBL20785353 0.72 MAOA (0.46) MAOAMAOBATMCYP2C9HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0940394-B1 Chemical process SYNGENTA LTD (GB) 2002-03-27 EP disclosed
EP-0592435-B1 PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS ZENECA LTD (GB) 2000-07-12 EP disclosed
EP-0940394-A1 Chemical process ZENECA LIMITED (GB) 1999-09-08 EP disclosed
US-5847138-A Chemical process IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1998-12-08 US disclosed
US-5760250-A CYCLIZATION, ALKENYLATION, ETHERIFICATION TO FORM FUNGICIDES ZENECA LIMITED (GB) 1998-06-02 US disclosed
EP-0592435-A1 PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS ZENECA LIMITED (GB) 1994-04-20 EP disclosed
WO-1992008703-A1 PROCESS FOR THE PREPARATION OF PYRIMIDINE COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-05-29 WO disclosed