Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 15/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.44 |
| ▸ | F10 | P00742 | 5/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 8/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462123 | 0.87 | ADORA2A (0.48) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7463401 | 0.85 | ITGB3 (0.45) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7452003 | 0.84 | ITGB3 (0.46) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7462112 | 0.82 | ADORA2A (0.54) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7458402 | 0.80 | ITGB3 (0.53) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7463795 | 0.79 | ITGB3 (0.45) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7466423 | 0.79 | ITGB3 (0.51) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL7457527 | 0.78 | ADORA2A (0.43) | PRSS1ITGB3ITGA2BPRSS2PRSS3 | |
| SCHEMBL8893573 | 0.77 | ADORA2A (0.48) | — | |
| SCHEMBL8892462 | 0.77 | ITGB3 (0.49) | ITGB3ITGA2BF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | claimed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | claimed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |