Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 9/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456006 | 0.97 | ADORA2B (0.34) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL8660273 | 0.88 | ADORA2B (0.33) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL8657823 | 0.87 | USP2 (0.33) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL10650075 | 0.74 | MEN1 (0.35) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL4445212 | 0.70 | KDM4E (0.51) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL3228294 | 0.68 | ATM (0.46) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL12152136 | 0.68 | PDE4A (0.40) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL7460040 | 0.66 | TNF (0.63) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL3235516 | 0.65 | SMN1; SMN2 (0.49) | USP2KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8660274 | 0.65 | CNOT7 (0.49) | ADORA2BADORA3ADORA2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |