Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417309 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TET2MAPTKEAP1NFE2L2 | |
| SCHEMBL7868945 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TET2MAPTKEAP1NFE2L2 | |
| SCHEMBL4009654 | 0.75 | ALDH1A1 (0.35) | ALDH1A1TET2MAPTHPGDRECQL | |
| SCHEMBL7461903 | 0.75 | TSHR (0.37) | HCAR2 | |
| SCHEMBL7463697 | 0.75 | NPSR1 (0.52) | ALDH1A1MAPT | |
| SCHEMBL11321706 | 0.73 | MAPT (0.39) | ALDH1A1TET2MAPTHPGD | |
| SCHEMBL2474496 | 0.69 | ALDH1A1 (0.43) | ALDH1A1MAPTHPGDRECQLKEAP1 | |
| SCHEMBL28347468 | 0.69 | L3MBTL1 (0.31) | ALDH1A1L3MBTL1 | |
| SCHEMBL10377692 | 0.67 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDRECQLKEAP1 | |
| SCHEMBL10971698 | 0.65 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRECQLKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916674-B1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-05-08 | — | — | EP | disclosed |
| US-6342603-B1 | PREPARING CYCLOPROPANE RING-CLEAVED PURINE DERIVATIVE BY HYDROGENATING PURINE DERIVATIVE HAVING CYCLOPROPANE RING | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-01-29 | — | — | US | disclosed |
| US-6156892-A | Purine derivatives having cyclopropane ring | SUMIKA FIRE CHEMICALS CO., LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0916674-A1 | Purine derivatives having cyclopropane ring | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| EP-0033863-A1 | Process for the production of cis-bicyclo (3.3.0)octane-3,7-dione, and its use | MERCK PATENT GmbH (DE) | 1981-08-19 | — | — | EP | disclosed |