SCHEMBL7457601

SCHEMBL7457601

CC(C)(C)OC(=O)C(C(=O)O)c1ccc(CN)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.40
LMNA P02545 3/20 0.39
KMT2A Q03164 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
NR1H2 P55055 1/20 0.39
KDM4E B2RXH2 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
BACE1 P56817 1/20 0.36
SRC P12931 1/20 0.35
PTGS1 P23219 4/20 0.35
PTGS2 P35354 4/20 0.35
CYP2C9 P11712 3/20 0.35
AKR1C3 P42330 2/20 0.35
CXCR1 P25024 2/20 0.35
CXCR2 P25025 2/20 0.35
NFKB1 P19838 2/20 0.35
ALB P02768 1/20 0.35
ESR1 P03372 1/20 0.35
ALOX5 P09917 1/20 0.35
RARB P10826 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14975818 0.86 SLC7A5 (0.45) SLC7A5LMNAKMT2ALOXL2NR1H2
SCHEMBL5239448 0.83 LMNA (0.42) SLC7A5LMNAKMT2ANR1H2KDM4E
SCHEMBL855255 0.81 LOXL2 (0.41) SLC7A5LMNAKMT2ALOXL2NR1H2
SCHEMBL11250163 0.81 KMT2A (0.43) LMNAKMT2ASRCESR1BLM
SCHEMBL28064960 0.80 SRC (0.57) LMNAKMT2ASRCCYP2D6
SCHEMBL3335866 0.80 SRC (0.57) LMNAKMT2ASRCCYP2D6
SCHEMBL5983603 0.80 SRC (0.57) LMNAKMT2ASRCCYP2D6
Ammonia Solution, Strong SCHEMBL23885016 0.80 LOXL2 (0.40) SLC7A5LMNAKMT2ALOXL2NR1H2
SCHEMBL28216971 0.80 SRC (0.54) LMNALOXL2KDM4ESMN1; SMN2BACE1
SCHEMBL1818550 0.79 SLC7A5 (0.53) SLC7A5LMNAKMT2AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250170253-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2025-05-29 US disclosed
US-20220265841-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2022-08-25 US disclosed
EP-3875082-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS Endocyte, Inc. (US) 2021-09-08 EP disclosed
EP-3858341-A1 PSMA LIGAND-CONTAINING CONJUGATES FOR THE TREATMENT OF PROSTATE CANCER Endocyte, Inc. (US) 2021-08-04 EP disclosed
US-20210154312-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2021-05-27 US disclosed
US-20210154311-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2021-05-27 US disclosed
US-10912840-B2 Conjugates for treating diseases caused by PSMA expressing cells ENDOCYTE, INC. (US) 2021-02-09 US disclosed
US-20190314515-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2019-10-17 US disclosed
US-20180289826-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2018-10-11 US disclosed
US-20180271991-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2018-09-27 US disclosed
US-20170258932-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2017-09-14 US disclosed
US-9636413-B2 Conjugates for treating diseases caused by PSMA expressing cells ENDOCYTE, INC. (US) 2017-05-02 US disclosed
US-20160361376-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2016-12-15 US disclosed
US-20160361432-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (IN) 2016-12-15 US disclosed
US-20160361433-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE INC (US) 2016-12-15 US disclosed
US-20150297735-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. 2015-10-22 US disclosed
EP-2919774-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS Endocyte, Inc. (US) 2015-09-23 EP disclosed
CN-104797247-A Conjugates for treating diseases caused by PSMA-expressing cells ENDOCYTE INC 2015-07-22 CN disclosed
WO-2014078484-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS ENDOCYTE, INC. (US) 2014-05-22 WO disclosed
WO-2001027096-A9 AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS PROTHERICS MOLECULAR DESIGN LT (GB) 2001-07-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160361376-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20210154311-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20210154312-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20160361432-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20220265841-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20250170253-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20180271991-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20190314515-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20160361433-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20170258932-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-10912840-B2 Conjugates for treating diseases caused by PSMA expressing cells FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20180289826-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885
US-20150297735-A1 CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS FOLH1, KLK3, CD47 SLC7A5 1698/4885LMNA 3596/4885KMT2A 961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.