Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 1.00 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28085028 | 0.85 | LRRK2 (1.00) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL9911260 | 0.84 | LRRK2 (0.71) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL26784321 | 0.83 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL12609218 | 0.83 | LRRK2 (0.70) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL19203872 | 0.82 | LRRK2 (0.69) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL12893063 | 0.81 | ALK (0.77) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL13191368 | 0.81 | LRRK2 (0.67) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL21557830 | 0.81 | ALK (0.81) | LRRK2ALKINSRIGF1R | |
| SCHEMBL14993949 | 0.79 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL14994580 | 0.79 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576541-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | claimed |
| WO-2011151360-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | claimed |
| EP-2576541-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011151360-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |