Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.57 |
| ▸ | INSR | P06213 | 4/20 | 0.57 |
| ▸ | IGF1R | P08069 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.55 |
| ▸ | STK17B | O94768 | 1/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458726 | 0.83 | LRRK2 (1.00) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL12651275 | 0.76 | LRRK2 (0.56) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL19203872 | 0.76 | LRRK2 (0.69) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL13191368 | 0.75 | LRRK2 (0.67) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL21557830 | 0.75 | ALK (0.81) | LRRK2ALKINSRIGF1REGFR | |
| SCHEMBL9911260 | 0.73 | LRRK2 (0.71) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL12893063 | 0.73 | ALK (0.77) | LRRK2ALKINSRIGF1RJAK2 | |
| SCHEMBL30395442 | 0.73 | LRRK2 (0.65) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL2060438 | 0.73 | LRRK2 (0.65) | LRRK2ALKINSRIGF1RCDK7 | |
| SCHEMBL11916548 | 0.73 | ALK (1.00) | LRRK2ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257637-B1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS INC (US) | 2015-09-23 | — | — | EP | disclosed |
| US-20110118126-A1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS, INC. | 2011-05-19 | — | — | US | disclosed |
| US-20110118126-A1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS, INC. | 2011-05-19 | — | — | US | disclosed |
| WO-2009120795-A1 | METHODS OF CHEMOTYPE EVOLUTION | SUNESIS PHARMACEUTICALS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |