Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.67 |
| ▸ | CDK7 | P50613 | 1/20 | 0.67 |
| ▸ | CDK9 | P50750 | 1/20 | 0.67 |
| ▸ | AXL | P30530 | 1/20 | 0.66 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.58 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | MERTK | Q12866 | 1/20 | 0.56 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465782 | 0.83 | LRRK2 (0.59) | LRRK2CDK7CDK9ALKINSR | |
| SCHEMBL7458726 | 0.81 | LRRK2 (1.00) | LRRK2CDK7CDK9ALKINSR | |
| SCHEMBL30820003 | 0.80 | AXL (1.00) | AXLTYRO3MERTKTTK | |
| SCHEMBL21795951 | 0.80 | AXL (1.00) | AXLTYRO3MERTKTTK | |
| SCHEMBL13326002 | 0.79 | MAPT (0.71) | CDK7CDK9AXLTYRO3 | |
| SCHEMBL7450567 | 0.77 | LRRK2 (0.95) | LRRK2 | |
| SCHEMBL30394806 | 0.76 | MAPK3 (0.66) | LRRK2CDK7CDK9AXLMERTK | |
| SCHEMBL17644521 | 0.76 | LRRK2 (0.57) | LRRK2ALKINSRIGF1RZAP70 | |
| SCHEMBL7453900 | 0.76 | LRRK2 (0.97) | LRRK2 | |
| SCHEMBL12609218 | 0.75 | LRRK2 (0.70) | LRRK2CDK7CDK9ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |