Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.69 |
| ▸ | HTR7 | P34969 | 8/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | HTR6 | P50406 | 5/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467800 | 0.96 | HTR1A (0.75) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7666807 | 0.91 | HTR1A (0.62) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL7672833 | 0.90 | HTR1A (0.63) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL7662224 | 0.90 | HTR1A (0.63) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7818172 | 0.88 | HTR1A (0.67) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7461768 | 0.86 | HTR1A (0.60) | HTR1ASLC6A4DRD2ADRA1D | |
| SCHEMBL7461356 | 0.86 | HTR1A (0.76) | HTR1ASLC6A4HTR7KCNH2HTR6 | |
| Hydrochloric Acid SCHEMBL7668625 | 0.85 | HTR1A (0.58) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL6637107 | 0.84 | HTR1A (1.00) | HTR1ASLC6A4HTR7KCNH2ADRA1D | |
| SCHEMBL6637104 | 0.84 | HTR1A (1.00) | HTR1ASLC6A4HTR7KCNH2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073651-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2002-09-25 | — | — | EP | claimed |
| EP-1073651-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6066637-A | NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-23 | — | — | US | disclosed |