SCHEMBL7459254

SCHEMBL7459254

Nc1c(Cl)cc(N(CCO)CCO)cc1-c1ccoc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 1/20 0.41
KMT2A Q03164 2/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
GAA P10253 1/20 0.32
PKM P14618 1/20 0.32
HTT P42858 1/20 0.32
MCL1 Q07820 1/20 0.32
ADORA2B P29275 1/20 0.31
ADORA1 P30542 1/20 0.31
GSK3B P49841 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7457559 0.84 MAPT (0.34) CSNK2A1KMT2AMAPTMEN1LMNA
SCHEMBL7460414 0.80 CSNK2A1 (0.35) CSNK2A1KMT2AMAPTMEN1LMNA
SCHEMBL7466570 0.76 CSNK2A1 (0.41) CSNK2A1ADORA2BADORA1GSK3B
SCHEMBL7805928 0.76 KMT2A (0.39) KMT2AMAPTMEN1LMNATP53
SCHEMBL7458650 0.76 CSNK2A1 (0.41) CSNK2A1ADORA2BADORA1GSK3B
SCHEMBL7465818 0.76 KMT2A (0.36) KMT2AMAPTMEN1LMNATP53
SCHEMBL7465675 0.76 MAPT (0.36) KMT2AMAPTMEN1LMNATP53
SCHEMBL7460696 0.76 CSNK2A1 (0.41) CSNK2A1ADORA2BADORA1GSK3B
SCHEMBL7456698 0.74 KMT2A (0.35) KMT2AMAPTMEN1LMNATP53
SCHEMBL7466976 0.74 CSNK2A1 (0.47) CSNK2A1KMT2AMEN1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP disclosed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US disclosed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP disclosed