Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.41 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL18109899 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL700300 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL547266 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL8128327 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL9614916 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL2169164 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL2565048 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL153300 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL6865127 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 | |
| Asparagine SCHEMBL17479548 | 0.96 | ALOX15 (0.48) | ALOX15BLMPMP22KMT2AGLRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003481-A4 | FIBRINOGEN-COATED MICROSPHERES | HEMOSPHERE INC (US) | 2002-10-23 | — | — | EP | disclosed |
| US-6264988-B1 | REDUCE BLEEDING TIME IN ANIMAL | HEMOSPHERE, INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1003481-A1 | FIBRINOGEN-COATED MICROSPHERES | HEMOSPHERE, INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998055105-A9 | FIBRINOGEN-COATED MICROSPHERES | HEMOSPHERE INC (US) | 1999-04-08 | — | — | WO | disclosed |
| WO-1998055105-A1 | FIBRINOGEN-COATED MICROSPHERES | HEMOSPHERE, INC. (US) | 1998-12-10 | — | — | WO | disclosed |