Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 7/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | ESRRA | P11474 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459582 | 1.00 | SCN9A (0.49) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7469547 | 0.90 | RXRA (0.51) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7469552 | 0.90 | RXRA (0.51) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7461821 | 0.89 | PIM1 (0.49) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7461818 | 0.89 | PIM1 (0.49) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7465806 | 0.88 | SCN9A (0.48) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7465810 | 0.88 | SCN9A (0.48) | SCN9AGSK3ANR1H4PIM1PIM2 | |
| SCHEMBL7463047 | 0.86 | ESRRA (0.53) | GSK3APIM1PIM2PTPN1ESRRA | |
| SCHEMBL7463041 | 0.86 | ESRRA (0.53) | GSK3APIM1PIM2PTPN1ESRRA | |
| SCHEMBL7460804 | 0.84 | GSK3A (0.52) | GSK3APIM1PIM2PTPN1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | claimed |
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |