Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 5/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465810 | 1.00 | SCN9A (0.48) | SCN9AGSK3BNR1H4PIM1PIM2 | |
| SCHEMBL7469547 | 0.88 | RXRA (0.51) | SCN9ANR1H4PIM1PIM2RXRA | |
| SCHEMBL7469552 | 0.88 | RXRA (0.51) | SCN9ANR1H4PIM1PIM2RXRA | |
| SCHEMBL7459582 | 0.88 | SCN9A (0.49) | SCN9AGSK3BNR1H4PIM1PIM2 | |
| SCHEMBL7461818 | 0.88 | PIM1 (0.49) | SCN9ANR1H4PIM1PIM2RXRA | |
| SCHEMBL7459574 | 0.88 | SCN9A (0.49) | SCN9AGSK3BNR1H4PIM1PIM2 | |
| SCHEMBL7461821 | 0.88 | PIM1 (0.49) | SCN9ANR1H4PIM1PIM2RXRA | |
| SCHEMBL7468651 | 0.86 | GSK3B (0.59) | GSK3BPIM1PIM2RXRAHPGD | |
| SCHEMBL7468657 | 0.86 | GSK3B (0.59) | GSK3BPIM1PIM2RXRAHPGD | |
| SCHEMBL14492769 | 0.83 | RXRA (0.55) | SCN9AGSK3BPIM1PIM2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | claimed |