Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 4/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468727 | 0.85 | CACNA1H (0.48) | CACNA1HCACNA1BTDP1PPARGPPARD | |
| SCHEMBL5206181 | 0.82 | TDP1 (0.47) | CACNA1HCACNA1BTDP1PPARGPPARD | |
| SCHEMBL5204003 | 0.81 | TDP1 (0.47) | CACNA1HCACNA1BTDP1PPARGPPARD | |
| SCHEMBL5206804 | 0.80 | PPARG (0.68) | PPARGPPARDPPARA | |
| SCHEMBL5757928 | 0.76 | PPARG (0.45) | CACNA1HCACNA1BTDP1PPARGPPARD | |
| SCHEMBL5759835 | 0.76 | PPARG (0.44) | CACNA1HCACNA1BTDP1PPARGPPARD | |
| SCHEMBL5204184 | 0.75 | TDP1 (0.57) | CACNA1HCACNA1BTDP1PPARGL3MBTL1 | |
| SCHEMBL8752495 | 0.71 | WDR5 (0.57) | CACNA1HCACNA1BL3MBTL1WDR5CYP2C9 | |
| SCHEMBL6940167 | 0.70 | PPARG (0.66) | PPARGPPARDPPARA | |
| SCHEMBL3552318 | 0.70 | GFER (0.56) | CACNA1HCACNA1BTDP1L3MBTL1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194146-A4 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-1194146-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078312-A1 | ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |