Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | EEF2K | O00418 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466381 | 0.93 | MEN1 (0.58) | EGFRERBB2MEN1KMT2ALMNA | |
| SCHEMBL7460683 | 0.91 | EGFR (0.50) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7461237 | 0.85 | MAPT (0.50) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7465966 | 0.84 | KDM4E (0.59) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7457358 | 0.83 | MEN1 (0.60) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7465913 | 0.80 | MAPT (0.56) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL28056488 | 0.80 | KDM4E (0.57) | EGFRMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL9052435 | 0.79 | MEN1 (0.60) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7466256 | 0.79 | KDM4E (0.56) | EGFRERBB2MEN1KMT2AHSP90AA1 | |
| SCHEMBL7466251 | 0.79 | KDM4E (0.56) | EGFRERBB2MEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5652250-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1997-07-29 | — | — | US | disclosed |
| EP-0700388-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-03-13 | — | — | EP | disclosed |
| WO-1995026341-A1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-10-05 | — | — | WO | disclosed |