Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | RGS12 | O14924 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461237 | 0.92 | MAPT (0.50) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL9052435 | 0.88 | MEN1 (0.60) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL7466381 | 0.85 | MEN1 (0.58) | MAPTRAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL28056488 | 0.85 | KDM4E (0.57) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL9053015 | 0.83 | KDM4E (0.45) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL7465966 | 0.82 | KDM4E (0.59) | MAPTRAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL7466256 | 0.81 | KDM4E (0.56) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL8830493 | 0.81 | KDM4E (0.56) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL7466251 | 0.81 | KDM4E (0.56) | MAPTNPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL7459907 | 0.80 | EGFR (0.57) | MAPTNPC1RAB9AL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |