Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | EEF2K | O00418 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459907 | 0.93 | EGFR (0.57) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL7465966 | 0.91 | KDM4E (0.59) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL7465913 | 0.85 | MAPT (0.56) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL7460683 | 0.84 | EGFR (0.50) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL28056488 | 0.83 | KDM4E (0.57) | MEN1KMT2AMAPTALDH1A1EGFR | |
| SCHEMBL7462857 | 0.82 | LMNA (0.62) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL9052435 | 0.82 | MEN1 (0.60) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL9053015 | 0.81 | KDM4E (0.45) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL24757961 | 0.80 | LMNA (0.58) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL7461237 | 0.80 | MAPT (0.50) | MEN1KMT2AHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700388-B1 | SUBSTITUTED BETA-ARYL AND BETA-HETEROARYL-ALPHA-CYANOACRYLAMIDE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-18 | — | — | EP | claimed |