SCHEMBL7459989

SCHEMBL7459989

CNc1ccc(N)cc1-c1ccoc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.36
CSNK2A1 P68400 1/20 0.36
TOP2A P11388 1/20 0.35
ALDH1A1 P00352 4/20 0.33
CYP1A2 P05177 4/20 0.33
CYP3A4 P08684 4/20 0.33
CLK4 Q9HAZ1 4/20 0.33
MEN1 O00255 3/20 0.33
CYP2D6 P10635 3/20 0.33
KMT2A Q03164 3/20 0.33
USP2 O75604 2/20 0.33
IMPDH2 P12268 2/20 0.33
HDAC2 Q92769 1/20 0.33
CYP2C19 P33261 2/20 0.33
HSD17B10 Q99714 2/20 0.33
FYN P06241 1/20 0.33
PTGES2 Q9H7Z7 1/20 0.32
CDK8 P49336 1/20 0.31
PELI1 Q96FA3 2/20 0.31
CCNT1 O60563 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3785429 0.78 ALDH1A1 (0.40) ALDH1A1CYP3A4MEN1KMT2AHSD17B10
SCHEMBL6001076 0.78 TOP2A (0.36) CSNK2A1TOP2AALDH1A1CYP1A2CYP3A4
SCHEMBL5795534 0.77 ALDH1A1 (0.43) RETCSNK2A1ALDH1A1CYP3A4MEN1
SCHEMBL7460535 0.77 CSNK2A1 (0.35) RETCSNK2A1TOP2AALDH1A1CYP1A2
SCHEMBL7465711 0.77 ALDH1A1 (0.45) CSNK2A1ALDH1A1CYP1A2CYP3A4CLK4
SCHEMBL7453950 0.77 CSNK2A1 (0.40) RETCSNK2A1ALDH1A1CYP1A2CYP3A4
SCHEMBL6574216 0.77 MAP4K4 (0.36) ALDH1A1CYP1A2CYP3A4MEN1KMT2A
Hydrochloric Acid SCHEMBL7453311 0.75 CSNK2A1 (0.42) RETCSNK2A1ALDH1A1CYP1A2CYP3A4
SCHEMBL3785718 0.75 MAOA (0.42) ALDH1A1CYP1A2CYP3A4MEN1KMT2A
SCHEMBL7461915 0.75 PTGER4 (0.43) ALDH1A1CYP1A2CYP3A4CLK4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP disclosed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US disclosed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP disclosed