Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HK1 | P19367 | 1/20 | 0.32 |
| ▸ | GALK1 | P51570 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460200 | 1.00 | LMNA (0.62) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7467661 | 0.77 | MAPT (0.92) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL27848261 | 0.74 | MAPT (0.46) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL18493810 | 0.74 | MAPT (0.49) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL18229432 | 0.73 | MAPT (0.45) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL6651141 | 0.73 | MAPT (0.38) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL5812357 | 0.70 | MAPT (0.36) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL28426030 | 0.70 | LMNA (0.46) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7460194 | 0.68 | LMNA (0.43) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7576472 | 0.68 | PLK1 (0.43) | LMNAHSP90AA1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |