Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.60 |
| ▸ | MMP13 | P45452 | 12/20 | 0.60 |
| ▸ | MMP1 | P03956 | 11/20 | 0.60 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | BMP1 | P13497 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460153 | 0.85 | MMP9 (0.72) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7461832 | 0.84 | MMP9 (0.73) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7457354 | 0.83 | MMP9 (0.60) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL6559726 | 0.81 | MMP9 (0.61) | MMP9MMP13MMP1MMP12LMNA | |
| SCHEMBL6559408 | 0.81 | MMP9 (0.60) | MMP9MMP13MMP1MMP12LMNA | |
| SCHEMBL7457791 | 0.80 | MMP9 (0.75) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL7463546 | 0.79 | MMP9 (0.59) | MMP9MMP13MMP1ADAM17 | |
| Hydroxyamine SCHEMBL8521994 | 0.79 | MMP9 (0.58) | MMP9MMP13MMP1MMP12LMNA | |
| SCHEMBL7463310 | 0.78 | MMP9 (0.74) | MMP9MMP13MMP1MMP12ADAM17 | |
| SCHEMBL7460162 | 0.78 | MMP9 (0.71) | MMP9MMP13MMP1MMP12ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934300-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2002-12-18 | — | — | EP | claimed |