Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.75 |
| ▸ | MMP13 | P45452 | 16/20 | 0.55 |
| ▸ | MMP1 | P03956 | 15/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463817 | 0.86 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6559727 | 0.83 | MMP9 (0.82) | MMP9MMP13MMP1ADAM17LMNA | |
| Hydroxyamine SCHEMBL8577454 | 0.82 | MMP9 (0.79) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL8577457 | 0.80 | MMP9 (0.76) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL7460437 | 0.80 | MMP9 (0.60) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL6559584 | 0.79 | MMP9 (0.75) | MMP9MMP13MMP1ADAM17LMNA | |
| SCHEMBL7460153 | 0.79 | MMP9 (0.72) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7010199 | 0.78 | MMP9 (0.69) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7009850 | 0.76 | MMP9 (0.76) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7005027 | 0.76 | MMP1 (0.76) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934300-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2002-12-18 | — | — | EP | claimed |