Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.61 |
| ▸ | PDE2A | O00408 | 4/20 | 0.61 |
| ▸ | PDE1A | P54750 | 2/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2643248 | 0.76 | PDE2A (0.61) | PDE3BPDE3APDE2AKMT2A | |
| SCHEMBL7289586 | 0.76 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10755622 | 0.75 | PDE3B (0.62) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10759777 | 0.74 | PDE3B (0.60) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7382611 | 0.73 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7290893 | 0.72 | PDE3B (0.59) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7461482 | 0.71 | PDE3B (0.58) | PDE3BPDE3APDE2APDE1APDE1B | |
| Tetrahydrobenximidazole SCHEMBL10625034 | 0.71 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7278083 | 0.71 | PDE3B (0.57) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10963015 | 0.71 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |