Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.66 |
| ▸ | PDE2A | O00408 | 3/20 | 0.66 |
| ▸ | PDE1A | P54750 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 14/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289586 | 0.80 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10962496 | 0.75 | PDE2A (0.64) | PDE3BPDE3APDE2AMAOB | |
| Tetrahydrobenximidazole SCHEMBL10625034 | 0.75 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10960086 | 0.72 | PDE3B (0.62) | PDE3BPDE3AMAOB | |
| SCHEMBL7382611 | 0.72 | PDE3B (1.00) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7290893 | 0.71 | PDE3B (0.59) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL7282912 | 0.71 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10833710 | 0.71 | PDE3B (0.66) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10960764 | 0.71 | MAOB (0.49) | PDE3BPDE3AMAOB | |
| SCHEMBL7461486 | 0.71 | PDE3B (0.61) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | claimed |
| EP-0149543-A1 | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4508718-A | Cardiotonic and antihypertensive oxadiazinone compounds | WARNER-LAMBERT COMPANY (US) | 1985-04-02 | — | — | US | disclosed |