Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470699 | 0.82 | OPRM1 (0.37) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL7478542 | 0.80 | GRIA2 (0.44) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL7469696 | 0.68 | GRIA1 (0.34) | GRIA4GRIA2 | |
| SCHEMBL1308581 | 0.64 | — | — | |
| SCHEMBL1309560 | 0.61 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL1310931 | 0.61 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL2629519 | 0.61 | OPRM1 (0.55) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL7468190 | 0.61 | GRIA2 (0.45) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL7469275 | 0.61 | GRIA2 (0.47) | OPRM1OPRD1OPRK1OPRL1NPY5R | |
| SCHEMBL6122214 | 0.60 | KMT2A (0.55) | HTTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |