Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.51 |
| ▸ | HTR1D | P28221 | 10/20 | 0.51 |
| ▸ | HTR1B | P28222 | 10/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22411096 | 0.89 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL7462311 | 0.86 | HTR1D (0.55) | HTR1AHTR1DHTR1BHTR2AHTR1F | |
| SCHEMBL7462602 | 0.82 | HTR1A (0.52) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL7460920 | 0.78 | HTR1A (0.51) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6342285 | 0.78 | HTR1A (0.64) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL6342480 | 0.77 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL6354568 | 0.76 | HTR1D (0.57) | HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL6346308 | 0.75 | HTR1A (0.63) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL6356041 | 0.74 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL7463036 | 0.74 | HTR1A (0.50) | HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140898-B1 | AMIDE AND UREA DERIVATIVES AS 5-HT REUPTAKE INHIBITORS AND AS 5-HT1B/1D LIGANDS | MERCK PATENT GMBH (DE) | 2002-08-28 | — | — | EP | disclosed |
| EP-1140898-A1 | AMIDE AND UREA DERIVATIVES AS 5-HT REUPTAKE INHIBITORS AND AS 5-HT1B/1D LIGANDS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037456-A1 | AMIDE AND UREA DERIVATIVES AS 5-HT REUPTAKE INHIBITORS AND AS 5-HT1B/1D LIGANDS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |