Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | TOP1 | P11387 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468329 | 0.90 | KCNH2 (0.55) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL7468336 | 0.90 | KCNH2 (0.55) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL7462916 | 0.85 | KCNH2 (0.34) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL15063055 | 0.82 | KDM4E (0.35) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL15062982 | 0.81 | KCNH2 (0.47) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL15062995 | 0.79 | KCNH2 (0.43) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL7461997 | 0.79 | KCNH2 (0.40) | KCNH2TOP1POLBCYP3A4 | |
| SCHEMBL15062879 | 0.79 | ALDH1A1 (0.42) | KCNH2TOP1ALDH1A1POLBOPRM1 | |
| SCHEMBL4262964 | 0.79 | KDM4E (0.41) | KCNH2TOP1ALDH1A1POLBKDM4E | |
| SCHEMBL3388793 | 0.78 | KCNH2 (0.38) | KCNH2TOP1ALDH1A1POLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900793-B1 | CYCLOALKYLAMINOMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2002-07-24 | — | — | EP | claimed |