Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | NMBR | P28336 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100777 | 0.75 | MEN1 (0.74) | SLC6A2FNTAFNTBSMN1; SMN2MEN1 | |
| SCHEMBL5849243 | 0.74 | ALDH1A1 (0.47) | SLC6A2SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4071928 | 0.73 | LMNA (0.70) | SLC6A2FNTAFNTBNMBRSMN1; SMN2 | |
| SCHEMBL7445365 | 0.73 | SLC6A2 (0.70) | SLC6A2FNTAFNTBNMBRSMN1; SMN2 | |
| SCHEMBL4071924 | 0.72 | SLC6A2 (0.53) | SLC6A2FNTAFNTBNMBRSMN1; SMN2 | |
| SCHEMBL7416001 | 0.72 | ALDH1A1 (0.45) | SLC6A2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9149723 | 0.71 | SMN1; SMN2 (0.73) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1167913 | 0.71 | TACR1 (0.77) | NMBRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL1167914 | 0.71 | TACR1 (0.77) | NMBRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL8025702 | 0.71 | TACR1 (0.77) | NMBRSMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629199-B1 | INDOLE DERIVATIVES AS 5-HT1 AGONISTS | PFIZER (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5717102-A | Indole derivatives as 5-HT1 agonists | PFIZER INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5594014-A | Indole derivatives as 5-HT1 agonists | PFIZER INC (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1993018032-A1 | INDOLE DERIVATIVES AS 5-HT1 AGONISTS | PFIZER INC. (US) | 1993-09-16 | — | — | WO | disclosed |