Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868781 | 0.85 | MAPT (0.42) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7459390 | 0.83 | GSK3B (0.46) | LMNARAB9AKMT2AVNN1 | |
| SCHEMBL8987286 | 0.76 | NPC1 (0.69) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27597149 | 0.75 | SERPINE1 (0.43) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1133114 | 0.74 | ATM (0.71) | ERCC5FEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL31514279 | 0.74 | ATM (0.71) | ERCC5FEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL27615911 | 0.73 | WNT3A (0.44) | ALDH1A1SMN1; SMN2SERPINE1MAPTRAB9A | |
| SCHEMBL27615863 | 0.73 | RAB9A (0.46) | ALDH1A1SMN1; SMN2SERPINE1MAPTRAB9A | |
| SCHEMBL14982192 | 0.73 | ERCC5 (0.74) | ERCC5FEN1ALDH1A1SMN1; SMN2LMNA | |
| Ammonia Solution, Strong SCHEMBL28227232 | 0.72 | ATM (0.68) | ERCC5FEN1ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |